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Three-dimensional molecular-field analyses of octopaminergic agonists for the cockroach neuronal octopamine receptor.

Abstract：

:The quantitative structure-activity relationship of a set of 40 octopaminergic agonists against receptor 2 in cockroach nervous tissue, was analyzed using molecular-field analysis (MFA). MFA on the study set of those compounds evaluated effectively the energy between a probe and a molecular model at a series of points defined by a rectangular grid. Contour surfaces for the molecular fields were presented and the results provided useful information in the characterization and differentiation of octopaminergic receptor.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Hirashima A,Morimoto M,Kuwano E,Eto M

doi

10.1016/s0968-0896(03)00313-4

subject

Has Abstract

pub_date

2003-08-15 00:00:00

pages

3753-60

issue

17

eissn

0968-0896

issn

1464-3391

pii

S0968089603003134

journal_volume

11

pub_type

杂志文章

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