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A new modification of anti-tubercular active molecules.

Abstract：

:The connection of two active molecules across an easily released bridge as a new type of potentially active molecule has been studied. The synthesis is based on derivatives that originate from isonicotinoyl hydrazide, pyrazinamide, p-aminosalicylic acid (PAS), ethambutol, and ciprofloxacin. The lipophilicity, hydrolysis (stability of the compounds), and antituberculotic activity as well as the structure-lipophilicity and structure-activity relationships are discussed.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Imramovský A,Polanc S,Vinsová J,Kocevar M,Jampílek J,Recková Z,Kaustová J

doi

10.1016/j.bmc.2007.01.051

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

2551-9

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00077-6

journal_volume

15

pub_type

杂志文章

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