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Complex molecules, clever solutions - Enzymatic approaches towards natural product and active agent syntheses.

Abstract：

:Natural compounds are often structurally complex and their synthesis is still highly challenging. The review intends to give an overview on developments in biotechnology and their role for the production of natural products and active agents. In vitro and in vivo methods are presented side by side beginning with rather simple but smart single step conversions, followed by cascade reactions, and finishing with complex bio-, semi- and mutasynthesis endeavours. All the enzymatic approaches do obviously complement traditional synthetic methods; with their particular strengths, the combined repertoire will lead to an increased efficiency in natural product synthesis as well as in providing analogues.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Classen T,Pietruszka J

doi

10.1016/j.bmc.2017.06.045

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

1285-1303

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(17)30217-1

journal_volume

26

pub_type

杂志文章,评审

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