Abstract：
:The fungus Aspergillus japonicus MF275 produces himeic acid A (1), containing a 4-pyrone ring, along with its congeners, himeic acids B (2) and C (3). During culture, 1 was gradually converted to 3, the corresponding 4-pyridone derivative. A study of the relationship between the culture pH and the fungal metabolites showed that a decrease from pH 6.5 to pH 2 is essential for production of 1, while a subsequent increase to pH 5 is necessary for production of 3. In addition, we revealed that 1 was non-enzymatically converted to 3 by the incorporation of an ammonium nitrogen atom in a pH 5 buffer, and that 1 was converted to 2 at a conversion ratio of 50% during incubation in MeOH for five days.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Katsuki A,Kato H,Tahara Y,Hashimoto M,Fujii I,Tsukamoto Sdoi
10.1016/j.bmc.2018.02.034subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1869-1874issue
8eissn
0968-0896issn
1464-3391pii
S0968-0896(18)30136-6journal_volume
26pub_type
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