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Scutione, a new bioactive norquinonemethide triterpene from Maytenus scutioides (Celastraceae).

Abstract：

:Scutione (1), a new norquinonemethide triterpene with a netzahualcoyene type skeleton, has been isolated from the root bark of Maytenus scutioides (Celastraceae) by bioactivity-directed fractionation. The structure of 1 has been elucidated by means of 1H and 13C NMR spectroscopic studies, including 1H-13C heteronuclear correlation (HETCOR), a long-range correlation spectrum with inverse detection (HMBC) and ROESY experiments. Compound 1 showed antibiotic activity against Gram-positive bacteria and modest cytotoxic activity against HeLa, Hep-2 and Vero cell lines. Fluoride derivatives 2-4 were prepared and assayed for bioactivity, where 2 showed slight improvement of the cytotoxic potency.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

González AG,Alvarenga NL,Ravelo AG,Bazzocchi IL,Ferro EA,Navarro AG,Moujir LM

doi

10.1016/0968-0896(96)00078-8

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

815-20

issue

6

eissn

0968-0896

issn

1464-3391

pii

0968-0896(96)00078-8

journal_volume

4

pub_type

杂志文章

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