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5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium.

Abstract：

:5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC(50)=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC(50)=100 nM) in cell proliferation assay without cytotoxicity on the transformed and cancer cell lines.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Son KH,Kwon JY,Jeong HW,Kim HK,Kim CJ,Chang YH,Choi JD,Kwon BM

doi

10.1016/s0968-0896(01)00268-1

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

185-8

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968089601002681

journal_volume

10

pub_type

杂志文章

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