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Phosphoenolpyruvate as a dual purpose reagent for integrated nucleotide/nicotinamide cofactor recycling.

Abstract：

:An efficient technique is presented which integrates cofactor dependent enzymic phosphorylation and dehydrogenation into a single, closed-loop system by employing phosphoenolpyruvate as the sacrificial reagent for sequential ATP and NAD+ recycling steps. Exemplary applications are developed for the synthesis of 6-phosphogluconate from glucose, and that of dihydroxyacetone phosphate from glycerol. The latter system is combined with exergonic diastereoselective aldol additions for the one-flask synthesis of a ketosugar (D-sorbose), thiosugar (L-threo-5-thiopentulose), or a sugar acid (L-threo-pent-4-ulosonic acid) starting from a mixture of glycerol and simple aldehydes.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Fessner WD,Sinerius G

doi

10.1016/0968-0896(94)85012-7

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

639-45

issue

7

eissn

0968-0896

issn

1464-3391

journal_volume

2

pub_type

杂志文章

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