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Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes.

Abstract：

:The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Tani H,Hasumi K,Tatefuji T,Hashimoto K,Koshino H,Takahashi S

doi

10.1016/j.bmc.2009.11.007

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

151-7

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)01015-3

journal_volume

18

pub_type

杂志文章

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