Cyanocobalamin (vitamin B12) conjugates with enhanced solubility.

Abstract:

:Cyanocobalamin (vitamin B12) is an essential nutrient as well as a very useful carrier in drug delivery. Conjugates of vitamin B12 are investigated due to their wide range of therapeutic applications. We report the synthesis of six vitamin B12 conjugates, and the effect of conjugation on their solubilities and stabilities in various media. We reveal here that vitamin B12 can be released readily if a 2'-hydroxyl group is conjugated rather than the 5'-hydroxyl group, and the solubility (thus the equivalents of vitamin B12) could be enhanced as much as 19-fold, by simple conjugates such as glycolates. Findings disclosed here provide insights into the reactivities of vitamin B12 conjugates, the design of future prodrugs and similar conjugated moieties using vitamin B12.

journal_name

Bioorg Med Chem

authors

Wang X,Wei L,Kotra LP

doi

10.1016/j.bmc.2006.11.036

subject

Has Abstract

pub_date

2007-02-15 00:00:00

pages

1780-7

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)00980-1

journal_volume

15

pub_type

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