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Synthesis of plaunotol derivatives and their antibacterial activities against Helicobacter pylori.

Abstract：

:Plaunotol, a known antiulcer drug, has antibacterial activities against Helicobacter pylori. Plaunotol thiourea derivatives 2--4 and diol derivatives 6--10 were designed in search for a compound with high antibacterial activities. Thiourea derivatives 2--4 were synthesized regioselectively using our effective synthetic route for plaunotol (1), and diol derivatives 6--10 were also synthesized. Their antibacterial activities against H. pylori are described and we found that the most potent antibacterial agent was C1-thiourea derivative 2c.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Tago K,Minami E,Masuda K,Akiyama T,Kogen H

doi

10.1016/s0968-0896(01)00080-3

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

1781-91

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(01)00080-3

journal_volume

9

pub_type

杂志文章

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