Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.

Abstract:

:The synthesis of 7-oxo and 7-hydroxy trifluoroallocolchicinoids was achieved through the intramolecular cyclization of o-phenyl-β-phenylalanines. The resulting compounds were evaluated for their cytotoxic activity against KB cells and their inhibitory effect towards the polymerization of tubulin. The results yielded some potent cytotoxic compounds with correlated partial antitubulin effect.

journal_name

Bioorg Med Chem

authors

Chosson E,Santoro F,Rochais C,Santos JS,Legay R,Thoret S,Cresteil T,Sinicropi MS,Besson T,Dallemagne P

doi

10.1016/j.bmc.2012.02.043

subject

Has Abstract

pub_date

2012-04-15 00:00:00

pages

2614-23

issue

8

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(12)00145-9

journal_volume

20

pub_type

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