Abstract:
:The synthesis of 7-oxo and 7-hydroxy trifluoroallocolchicinoids was achieved through the intramolecular cyclization of o-phenyl-β-phenylalanines. The resulting compounds were evaluated for their cytotoxic activity against KB cells and their inhibitory effect towards the polymerization of tubulin. The results yielded some potent cytotoxic compounds with correlated partial antitubulin effect.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Chosson E,Santoro F,Rochais C,Santos JS,Legay R,Thoret S,Cresteil T,Sinicropi MS,Besson T,Dallemagne Pdoi
10.1016/j.bmc.2012.02.043subject
Has Abstractpub_date
2012-04-15 00:00:00pages
2614-23issue
8eissn
0968-0896issn
1464-3391pii
S0968-0896(12)00145-9journal_volume
20pub_type
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