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Chemiluminescence flow sensor for berberine with immobilized reagents.

Abstract：

:A sensitive chemiluminescence (CL) sensor for berberine combined with flow-injection (FI) technology is described. The analytical reagents involved in the CL reaction, including luminol and potassium ferricyanide, were both immobilized on an anion-exchange resin column. While a volume of sodium phosphate was passed through the column, the two CL reagents were eluted from the resin and then mixed with a berberine stream under alkaline conditions. By means of the fast oxidation reaction between berberine and potassium ferricyanide, potassium ferrocyanide was generated, which then inhibited the CL reaction of luminol and potassium ferricyanide. The decreased CL intensity was correlated with the berberine concentration in the range from 0.05 to 300 ng mL(-1 )with a relative standard deviation of less than 4.3%, and the limit of detection was 0.02 ng mL(-1) at a flow rate of 2.0 mL min(-1). It was shown that the flow sensor could greatly improve the selectivity and sensitivity for determination of berberine. The determination of analyte could be performed in 2 min, including sampling and washing and be stable for over 300 analyses. Some interference and additives in preparations were tested. Two herbal medicines commonly found in compound prescriptions, rutin and baicalin, were studied preliminarily. The method has been applied for the determination of berberine in pharmaceutical preparations successfully.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Song Z,Zhao T,Wang L,Xiao Z

doi

10.1016/s0968-0896(01)00069-4

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

1701-5

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(01)00069-4

journal_volume

9

pub_type

杂志文章

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