Abstract:
:Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Mazu TK,Etukala JR,Zhu XY,Jacob MR,Khan SI,Walker LA,Ablordeppey SYdoi
10.1016/j.bmc.2010.10.065subject
Has Abstractpub_date
2011-01-01 00:00:00pages
524-33issue
1eissn
0968-0896issn
1464-3391pii
S0968-0896(10)01003-5journal_volume
19pub_type
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