Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens.

Abstract:

:Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived.

journal_name

Bioorg Med Chem

authors

Mazu TK,Etukala JR,Zhu XY,Jacob MR,Khan SI,Walker LA,Ablordeppey SY

doi

10.1016/j.bmc.2010.10.065

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

524-33

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)01003-5

journal_volume

19

pub_type

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