当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY期刊下所有文献 > Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers.

Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers.

Abstract：

:A series of pyrrolobenzodiazepine-naphthalimide conjugates tethered through a piperazine ring system have been designed, synthesized, and evaluated for their anticancer activity. These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Kamal A,Ramu R,Tekumalla V,Khanna GB,Barkume MS,Juvekar AS,Zingde SM

doi

10.1016/j.bmc.2008.06.034

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

7218-24

issue

15

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)00580-4

journal_volume

16

pub_type

杂志文章

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