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Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery.

Abstract：

:A concise and efficient synthesis of cyclopentitols as a scaffold for a two-dimensional compound library for drug discovery is described. Starting from d-mannose, the key steps are Wittig olefination and ring-closing metathesis (RCM) followed by a [3,3]-sigmatropic Overmann rearrangement to form an sp(3)-rich, natural product-like scaffold from which a focused compound library with different functionalities is prepared.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Padwal JD,Filippov DV,Narhe BD,Aertssen S,Beuving RJ,Benningshof JC,van der Marel GA,Overkleeft HS,van der Stelt M

doi

10.1016/j.bmc.2015.01.040

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

2650-5

issue

11

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(15)00064-4

journal_volume

23

pub_type

杂志文章

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