Abstract:
:It looks that a new era of antimicrobial peptides (AMPs) started with the discovery of teixobactin, which is a "head to side-chain" cyclodepsipeptide. It was isolated from a soil gram-negative b-proteobacteria by means of a revolutionary technique. Since there, several groups have developed synthetic strategies for efficient synthesis of this peptide and its analogues as well. Herein, all chemistries reported as well as the biological activity of the analogues are analyzed. Finally, some inputs regarding new trends for the next generation of analogues are discussed.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Abdel Monaim SAH,Jad YE,El-Faham A,de la Torre BG,Albericio Fdoi
10.1016/j.bmc.2017.09.040subject
Has Abstractpub_date
2018-06-01 00:00:00pages
2788-2796issue
10eissn
0968-0896issn
1464-3391pii
S0968-0896(17)31609-7journal_volume
26pub_type
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