Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study.

Abstract:

:It looks that a new era of antimicrobial peptides (AMPs) started with the discovery of teixobactin, which is a "head to side-chain" cyclodepsipeptide. It was isolated from a soil gram-negative b-proteobacteria by means of a revolutionary technique. Since there, several groups have developed synthetic strategies for efficient synthesis of this peptide and its analogues as well. Herein, all chemistries reported as well as the biological activity of the analogues are analyzed. Finally, some inputs regarding new trends for the next generation of analogues are discussed.

journal_name

Bioorg Med Chem

authors

Abdel Monaim SAH,Jad YE,El-Faham A,de la Torre BG,Albericio F

doi

10.1016/j.bmc.2017.09.040

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

2788-2796

issue

10

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(17)31609-7

journal_volume

26

pub_type

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