Abstract:
:In the present study, we report that three new lupane triterpenes (1-3), in addition to 16 known ones (4-19), were isolated from the root bark of Maytenus cuzcoina and the leaves of Maytenus chiapensis. Their structures were elucidated by spectral analysis, including homonuclear and heteronuclear correlation NMR experiments (COSY, ROESY, HSQC, and HMBC). The natural compounds and derivatives 6a, 6b, 9a, and 9b have been tested for potential anti-inflammatory activity, and several compounds including 3-epicalenduladiol (2), 11alpha-hydroxy-glochidone (3), rigidenol (6), acetoxy-rigidenol (6a), 11alpha-acetoxy-30-chloro-3-oxo-lup-20(29)-ene (6b), betulin (9), 28-acetoxy-betulin (9a), epibetulin (12), epibetulinic acid (13), and betulonic acid (16) exhibited potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin. The structure-activity relationship is discussed in detail.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Reyes CP,Núñez MJ,Jiménez IA,Busserolles J,Alcaraz MJ,Bazzocchi ILdoi
10.1016/j.bmc.2005.10.063subject
Has Abstractpub_date
2006-03-01 00:00:00pages
1573-9issue
5eissn
0968-0896issn
1464-3391pii
S0968-0896(05)01072-2journal_volume
14pub_type
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