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Synthesis of glycosylated beta-amino hydroxamates as new class of antimalarials.

Abstract：

:Glycosylated beta-amino acids (3-18, 38, 39), obtained by hydrolysis of glycosylated beta-amino esters on reaction with hydroxylamine hydrochloride in presence of DIC/DCC afforded glycosyl beta-amino hydroxamates (19-34, 40, 41) in fair to good yields. Compounds (19-34, 40, 41) were screened against human malarial parasite Plasmodium falciparum in vitro for their schizontocidal activity. Compounds (19, 24, 26, 28, 40 and 41) exhibited good activity at 2 microg/mL concentrations.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Mishra RC,Tripathi R,Katiyar D,Tewari N,Singh D,Tripathi RP

doi

10.1016/j.bmc.2003.09.038

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

5363-74

issue

24

eissn

0968-0896

issn

1464-3391

pii

S0968089603006655

journal_volume

11

pub_type

杂志文章

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