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Synthesis and evaluation of antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids.

Abstract：

:The synthesis and antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids 8-58 is described. Trifluoromethylpyridine derivatives 8-58 were evaluated for their anticancer activity toward human tumoral cell lines by the National Cancer Institute (NCI). Most of them possess encouraging anticancer activity, having GI(50) values in the low micromolar to nanomolar concentration range. The 3,4,5-trimethoxyphenylamide 44 was the most active, and it is now under review by NCI Biological Evaluation Committee for possible further studies.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Onnis V,Cocco MT,Lilliu V,Congiu C

doi

10.1016/j.bmc.2007.11.069

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

2367-78

issue

5

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)01037-1

journal_volume

16

pub_type

杂志文章

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