Abstract:
:The synthesis and antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids 8-58 is described. Trifluoromethylpyridine derivatives 8-58 were evaluated for their anticancer activity toward human tumoral cell lines by the National Cancer Institute (NCI). Most of them possess encouraging anticancer activity, having GI(50) values in the low micromolar to nanomolar concentration range. The 3,4,5-trimethoxyphenylamide 44 was the most active, and it is now under review by NCI Biological Evaluation Committee for possible further studies.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Onnis V,Cocco MT,Lilliu V,Congiu Cdoi
10.1016/j.bmc.2007.11.069subject
Has Abstractpub_date
2008-03-01 00:00:00pages
2367-78issue
5eissn
0968-0896issn
1464-3391pii
S0968-0896(07)01037-1journal_volume
16pub_type
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