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Synthesis and antitumor activity of goniofufurone analogues.

Abstract：

:Synthesis and antitumor activity of goniofufurone analogues 15, 16, 17, 33, and 46 is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans 18, 19 to the corresponding lactols 32, 43. Cytotoxicities of 15, 16, 17, 33, and 46 tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone (1) did not enhance the cytotoxicities significantly.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Mereyala HB,Gadikota RR,Joe M,Arora SK,Dastidar SG,Agarwal S

doi

10.1016/s0968-0896(99)00164-9

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

2095-103

issue

9

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(99)00164-9

journal_volume

7

pub_type

杂志文章

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