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N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents.

Abstract：

:A range of N-phenethyl, N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared by N-alkylation reactions. Their activity against human monocyte-like histiocytic lymphoma (U937), leukemia (Jurkat), and breast carcinoma (MDA-MB-231) cell lines was assessed. The results allowed further development of structure-activity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC(50) value of 0.19 microM.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Matesic L,Locke JM,Bremner JB,Pyne SG,Skropeta D,Ranson M,Vine KL

doi

10.1016/j.bmc.2007.12.026

subject

Has Abstract

pub_date

2008-03-15 00:00:00

pages

3118-24

issue

6

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)01078-4

journal_volume

16

pub_type

杂志文章

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