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Synthesis and biological evaluation of epothilone A dimeric compounds.

Abstract：

:The preparation and biological evaluation of a novel series of dimeric epothilone A derivatives (1-6) are described. Two types of diacyl spacers were introduced to establish the various dimeric epothilone A constructs. The effect of these compounds on tubulin polymerization and their cytotoxicity against four different cancer cell lines are reported. Several of the newly synthesized compounds inhibit endothelial cell differentiation and endothelial cell migration that are key steps of the angiogenic process.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Passarella D,Comi D,Cappelletti G,Cartelli D,Gertsch J,Quesada AR,Borlak J,Altmann KH

doi

10.1016/j.bmc.2009.09.032

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

7435-40

issue

21

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00884-0

journal_volume

17

pub_type

杂志文章

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