当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY期刊下所有文献 > Structure-activity relationships in platelet-activating factor. Part 14: synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity.

Structure-activity relationships in platelet-activating factor. Part 14: synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity.

Abstract：

:As HIV-associated dementia prevalence has risen with the lifespan of HIV-infected individuals, there is an important need for antiretroviral and anti-inflammatory drugs targeting the central nervous system. Platelet-activating factor, a mediator of inflammation, is an HIV-induced neurotoxin secreted in the infected brain. In this work, we developed piperazine derivatives bearing a heterocyclic moiety as PAF-antagonists and HIV-1 replication inhibitors with micromolar potency.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Sallem W,Serradji N,Dereuddre-Bosquet N,Dive G,Clayette P,Heymans F

doi

10.1016/j.bmc.2006.07.043

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

7999-8013

issue

23

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)00597-9

journal_volume

14

pub_type

杂志文章

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