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Synthesis and in vitro characterization of platinum(II) anticancer coordinates using FTIR spectroscopy and NCI COMPARE: A fast method for new compound discovery.

Abstract：

:Platinum-based drugs have been used for several decades to treat various cancers successfully. Cisplatin is the original compound in this class; it cross-links DNA, resulting in cell cycle arrest and cell death via apoptosis. Cisplatin is effective against several tumor types but exhibits toxic side effects; in addition, tumors often develop resistance. An original in vitro approach is proposed to determine whether platinum-based research compounds are good candidates for further study by comparing them to marketed drugs using FTIR spectroscopy and the COMPARE analysis from the NCI. Both methods can produce fingerprints and highlight differences between the compounds, classifying the candidates and revealing promising derivatives.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Berger G,Leclercqz H,Derenne A,Gelbcke M,Goormaghtigh E,Nève J,Mathieu V,Dufrasne F

doi

10.1016/j.bmc.2014.04.017

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

3527-36

issue

13

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(14)00271-5

journal_volume

22

pub_type

杂志文章

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