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Synthesis and chain length-anti-HIV activity relationship of fully N- and O-sulfated homooligomers of tyrosine.

Abstract：

:Fully N- and O-sulfated homooligomers from octamer to nonadecamer of tyrosine were obtained as their sodium salts, aO3S-[Tyr(SO3Na)]n-ONa (n = 8-19), from reaction mixtures of tyrosine with sulfur trioxide trimethylamine and pyridine comlexes, respectively, in pyridine. Their anti-HIV activity increased along with the increase of the chain length up to the dodecamer, maintained the same level to the length of the heptadecamer and then decreased. The maximal activity level was the same as or higher than that of dextran and curdlan sulfates.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Ueki M,Watanabe S,Saitoh T,Nakashima H,Yamamoto N,Ogawara H

doi

10.1016/s0968-0896(00)00268-6

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

487-92

issue

2

eissn

0968-0896

issn

1464-3391

pii

S0968089600002686

journal_volume

9

pub_type

杂志文章

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