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HSP90-like artificial chaperone activity based on indole beta-cyclodextrin.

Abstract：

:Indole beta-cyclodextrin (beta-1) was found to be able to prevent aggregation of citrate synthase (CS) on heating condition. As a result, beta-1 showed anti-CS aggregation in this system by regulating in early stage. The depression mechanism of beta-1 for aggregation of CS is as follows: the beta-1 formed a complex with hydrophobic parts of the beta-sheet structure of CS. From CD spectra, CS was changed own conformation was changed by beta-1 addition. So, it was concluded that beta-1 works as beta-sheet inducer in thermal condition. On the other hand, native beta-cyclodextrin (beta-CyD) shows small suppression capability for CS aggregation.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Toda M,Itoh H,Kondo Y,Hamada F

doi

10.1016/j.bmc.2006.12.040

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

1983-8

issue

5

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)01045-5

journal_volume

15

pub_type

杂志文章

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