Bioorganic chemistry of cyclic ADP-ribose (cADPR).

abstract：:6-N-(Benzothiazol-2-yl)deoxyadenosine (A(BT)) was synthesized and incorporated into DNAs. Although, the multipoint benzothiazole (BT) modification of oligodeoxynucleotides reduced the stability of duplexes with their complementary strands, it induced the strong exciton coupling between BT moieties. The circular dichro...

journal_title：Bioorganic & medicinal chemistry

authors： Masaki Y,Ohkubo A,Seio K,Sekine M

更新日期：2010-01-15 00:00:00

abstract：:Thymidylate synthase (TS) (EC 2.1.1.45), an enzyme involved in the DNA synthesis of both prokaryotic and eukaryotic cells, is a potential target for the development of anticancer and antinfective agents. Recently, we described a series of phthalein and naphthalein derivatives as TS inhibitors. These compounds have str...

journal_title：Bioorganic & medicinal chemistry

authors： Ghelli S,Rinaldi M,Barlocco D,Gelain A,Pecorari P,Tondi D,Rastelli G,Costi MP

更新日期：2003-03-20 00:00:00

abstract：:Using hydroxy-/dihydroxybenzoic acids as leads, a series of methyl, ethyl and iso-propyl esters of 4-hydroxy-benzoic acid, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5-dihydroxybenzoic acids and of coumaric acid, were obtained and investigated for the inhibition of six mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms, that i...

journal_title：Bioorganic & medicinal chemistry

authors： Carta F,Vullo D,Maresca A,Scozzafava A,Supuran CT

更新日期：2013-03-15 00:00:00

abstract：:A novel series of fluorinated 2-phenylindole derivatives were synthesized and evaluated as β-amyloid imaging probes for PET. The in vitro inhibition assay demonstrated that their binding affinities for Aβ(1-42) aggregates ranged from 28.4 to 1097.8 nM. One ligand was labeled with (18)F ([(18)F]1a) for its high affinit...

journal_title：Bioorganic & medicinal chemistry

authors： Fu H,Yu L,Cui M,Zhang J,Zhang X,Li Z,Wang X,Jia J,Yang Y,Yu P,Jia H,Liu B

更新日期：2013-07-01 00:00:00

abstract：:The synthesis of a series of new isothiazol-3(2H)-one 1,1-dioxides with halogenated (mostly fluorinated) pyridinyl and pentafluorophenyl substituents at 2-position is reported. These compounds (18-24) became easily accessible from 2-thiocyanato-1-carboxaldehydes and aminopyridines, pentafluoroaniline, respectively, by...

journal_title：Bioorganic & medicinal chemistry

authors： Eilfeld A,González Tanarro CM,Frizler M,Sieler J,Schulze B,Gütschow M

更新日期：2008-09-01 00:00:00

abstract：:Posttranslational modification of proteins with ubiquitin and ubiquitin-like modifiers such as SUMO can be reverted by specific proteases, also referred to as deubiquitinases and isopeptidases, most of which are cysteine-dependent. We have found that the replacement of the conserved C-terminal glycine with propargylam...

journal_title：Bioorganic & medicinal chemistry

authors： Sommer S,Weikart ND,Linne U,Mootz HD

更新日期：2013-05-01 00:00:00

abstract：:4-methoxyphenyl glycosides of 2,3''-bis-alpha-L-arabinofuranosyl branched beta-D-(1-->6)-linked galactopyranosyl tetraose (16), 3',2''''-bis-alpha-L-arabinofuranosyl branched beta-D-(1-->6)-linked galactopyranosyl hexaose (27), and a twentyose (42) consisting of beta-(1-->6)-linked D-galactopyranosyl pentadecaoligosac...

journal_title：Bioorganic & medicinal chemistry

authors： Li A,Kong F

更新日期：2005-02-01 00:00:00

abstract：:Combinatorial biocatalysis, based on a principle of the combinatorial use of biosynthetic steps rather than the combinatorial use of reagents, offers a complementary approach to combinatorial chemistry, which, used individually or in connection with synthetic organic transformations, provides access to analogues not r...

journal_title：Bioorganic & medicinal chemistry

authors： Krstenansky JL,Khmelnitsky Y

更新日期：1999-10-01 00:00:00

abstract：:Identification of structural determinants required for potent inhibition of drug-metabolizing cytochrome P450 3A4 (CYP3A4) could help develop safer drugs and more effective pharmacoenhancers. We utilize a rational inhibitor design to decipher structure-activity relationships in analogues of ritonavir, a highly potent ...

journal_title：Bioorganic & medicinal chemistry

authors： Samuels ER,Sevrioukova IF

更新日期：2020-03-15 00:00:00

abstract：:We synthesized methylvesamicol analogs 13-16 and investigated the binding characteristics of 2-[4-phenylpiperidino]cyclohexanol (vesamicol) and methylvesamicol analogs 13-16, with a methyl group introduced into the 4-phenylpiperidine moiety, to sigma receptors (sigma-1, sigma-2) and to vesicular acetylcholine transpor...

journal_title：Bioorganic & medicinal chemistry

authors： Shiba K,Ogawa K,Ishiwata K,Yajima K,Mori H

更新日期：2006-04-15 00:00:00

abstract：:A group of (E)-3-(4-methanesulfonylphenyl)acrylic acids possessing a substituted-phenyl ring (4-H, 4-Br, 3-Br, 4-F, 4-OH, 4-OMe, 4-OAc, and 4-NHAc) attached to the acrylic acid C-2 position were prepared using a stereospecific Perkin condensation reaction. A related group of compounds having 4- and 3-(4-isopropyloxyph...

journal_title：Bioorganic & medicinal chemistry

authors： Moreau A,Chen QH,Praveen Rao PN,Knaus EE

更新日期：2006-12-01 00:00:00

abstract：:The 3-aryl-2-cyanoacrylamide scaffold was designed as core pharmacophore for inhibitors of the Dengue and West Nile virus serine proteases (NS2B-NS3). A total of 86 analogs was prepared to study the structure-activity relationships in detail. Thereby, it turned out that the electron density of the aryl moiety and the ...

journal_title：Bioorganic & medicinal chemistry

authors： Nitsche C,Steuer C,Klein CD

更新日期：2011-12-15 00:00:00

abstract：:Z-1,1-Dichloro-2,3-diphenylcyclopropane (1) is an effective anti-breast cancer agent in rodents and in cell culture. We recently determined that 1 inhibits tubulin assembly in vitro and causes microtubule loss in breast cancer cells, leading to accumulation in the G2/M portion of the cell cycle. Aryl ring-halogenated,...

journal_title：Bioorganic & medicinal chemistry

authors： Jonnalagadda SS,ter Haar E,Hamel E,Lin CM,Magarian RA,Day BW

更新日期：1997-04-01 00:00:00

abstract：:Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) in vitro, efficacy in T. b. r. STIB900 acute and T. b. brucei GVR35 CNS mouse models. Most diamidines gave poly(dA-dT)2...

journal_title：Bioorganic & medicinal chemistry

authors： Hu L,Patel A,Bondada L,Yang S,Wang MZ,Munde M,Wilson WD,Wenzler T,Brun R,Boykin DW

更新日期：2013-11-01 00:00:00

abstract：:Thirty-three meso-dihydroguaiaretic acid (meso-DGA) derivatives bearing esters, ethers, and amino-ethers were synthesized. All derivatives were tested against twelve drug-resistant clinical isolates of Gram-positive and Gram-negative bacteria, including sensitive (H37Rv) and multidrug-resistant Mycobacterium tuberculo...

journal_title：Bioorganic & medicinal chemistry

authors： Reyes-Melo K,García A,Romo-Mancillas A,Garza-González E,Rivas-Galindo VM,Miranda LD,Vargas-Villarreal J,Favela-Hernández JMJ,Camacho-Corona MDR

更新日期：2017-10-15 00:00:00

abstract：:Guanase is an important enzyme of the purine salvage pathway of nucleic acid metabolism and its inhibition has beneficial implications in viral, bacterial, and cancer therapy. The work described herein is based on a hypothesis that azepinomycin, a heterocyclic natural product and a purported transition state analog in...

journal_title：Bioorganic & medicinal chemistry

authors： Tantravedi S,Chakraborty S,Shah NH,Fishbein JC,Hosmane RS

更新日期：2013-09-01 00:00:00

abstract：:To streamline the preclinical phase of pharmaceutical development, we have explored the utility of structural data on the molecular target and synergy between computational and medicinal chemistry. We have concentrated on parasitic infectious diseases with a particular emphasis on the development of specific noncovale...

journal_title：Bioorganic & medicinal chemistry

authors： Li R,Chen X,Gong B,Selzer PM,Li Z,Davidson E,Kurzban G,Miller RE,Nuzum EO,McKerrow JH,Fletterick RJ,Gillmor SA,Craik CS,Kuntz ID,Cohen FE,Kenyon GL

更新日期：1996-09-01 00:00:00

abstract：:The problems inherent in the enzymatic and chemical synthesis of S-adenosyl-L-methionine (SAM) led us to develop an efficient, simple method for the synthesis of large amounts of labeled SAM. Previously, we reported that the problem of product inhibition of E. coli SAM synthetase encoded by the metK gene was successfu...

journal_title：Bioorganic & medicinal chemistry

authors： Park J,Tai J,Roessner CA,Scott AI

更新日期：1996-12-01 00:00:00

abstract：:Forty-five novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel cinnamic acid moieties at C-7 that were synthesized using a key Heck reaction followed by nucleophilic aromatic substitution reactions. The most active compound...

journal_title：Bioorganic & medicinal chemistry

authors： Springer DM,Luh BY,Goodrich J,Bronson JJ

更新日期：2003-01-17 00:00:00

abstract：:The aim of this work was to synthesize a set of heterocyclic derivatives of lupane, lup-20(29)-ene, and 18α-oleanane, and to investigate their cytotoxic activities. Some of those heterocycles were previously known in the oleanane (allobetulin) group; however, to our knowledge the syntheses and biological activities of...

journal_title：Bioorganic & medicinal chemistry

authors： Urban M,Vlk M,Dzubak P,Hajduch M,Sarek J

更新日期：2012-06-01 00:00:00

abstract：:Experimental and theoretical physico-chemical methods were used to investigate the interaction between several reversible monoamine oxidase A inhibitors in the oxazolidinone series and the active site of the enzyme. Phenyloxazolidinones include toloxatone and analogues, among which befloxatone was selected as drug can...

journal_title：Bioorganic & medicinal chemistry

authors： Wouters J,Moureau F,Evrard G,Koenig JJ,Jegham S,George P,Durant F

更新日期：1999-08-01 00:00:00

abstract：:Three different photoprobes were synthesized to label beta-glucosidases; one probe was based on glucose, two probes on the iminosugar deoxynojirimycin. The affinity of the probes for three different beta-glucosidases was determined. Furthermore, their labeling efficiencies, binding specificities through competition wi...

journal_title：Bioorganic & medicinal chemistry

authors： van Scherpenzeel M,van den Berg RJ,Donker-Koopman WE,Liskamp RM,Aerts JM,Overkleeft HS,Pieters RJ

更新日期：2010-01-01 00:00:00

abstract：:Reaction of γ-Boc-GABA, prepared by protecting the γ-amino moiety of the amino butyric acid with the tert-butyloxycarbonyl (Boc) protecting group, with 4-methyl/ethyl benzenesulfonamide, followed by removal of the Boc protecting group in 3 M HCl afforded the corresponding hydrochlorides, which were further derivatized...

journal_title：Bioorganic & medicinal chemistry

authors： Ceruso M,Antel S,Vullo D,Scozzafava A,Supuran CT

更新日期：2014-12-15 00:00:00

abstract：:Histone modification, for example, by histone deacetylase (HDAC) and histone lysine methyltransferase (HMT), plays an important role in regulating gene expression. To obtain novel inhibitors as tools for investigating the physiological function of members of the HMT family, we designed and synthesized novel inhibitors...

journal_title：Bioorganic & medicinal chemistry

authors： Mori S,Iwase K,Iwanami N,Tanaka Y,Kagechika H,Hirano T

更新日期：2010-12-01 00:00:00

abstract：:Protein geranylgeranylation reactions are dependent on the availability of geranylgeranyl diphosphate (GGDP), which serves as the isoprenoid donor. Inhibition of GGDP synthase (GGDPS) is of interest from a drug development perspective as GGDPS inhibition results in impaired protein geranylgeranylation, which in multip...

journal_title：Bioorganic & medicinal chemistry

authors： Wills VS,Metzger JI,Allen C,Varney ML,Wiemer DF,Holstein SA

更新日期：2017-04-15 00:00:00

abstract：:New sildenafil analogues containing an ether ring fused into the phenyl moiety, 6a--d and 7a--d, were efficiently synthesized from the readily available starting materials, 1a--d and 2, in five steps. Ab initio calculations indicated that introduction of a cyclic ether to the phenyl group might enhance the co-planarit...

journal_title：Bioorganic & medicinal chemistry

authors： Kim DK,Lee N,Lee JY,Ryu DH,Kim JS,Lee SH,Choi JY,Chang K,Kim YW,Im GJ,Choi WS,Kim TK,Ryu JH,Kim NH,Lee K

更新日期：2001-06-01 00:00:00

abstract：:In order to find novel and environmental friendly insecticides targeting the ryanodine receptor, three series of novel phthalamides containing heptafluoroisopropyl group, low fluorine atoms group and non-fluorine group were designed and synthesized. 35 novel structures of three series were obtained. Insecticidal activ...

journal_title：Bioorganic & medicinal chemistry

authors： Chen Y,Li Y,Pan L,Liu J,Wan Y,Chen W,Xiong L,Yang N,Song H,Li Z

更新日期：2014-11-15 00:00:00

abstract：:Cells have evolved complex biochemical pathways for DNA interstrand crosslink (ICL) removal. Despite the chemotherapeutic importance of ICL repair, there have been few attempts to identify which mechanistic DNA repair inhibitor actually inhibits ICL repair. To identify such compounds, a new and robust ICL repair assay...

journal_title：Bioorganic & medicinal chemistry

authors： Fujii N,Evison BJ,Actis ML,Inoue A

更新日期：2015-11-01 00:00:00

abstract：:Inhibitors of transglycosylases may serve as potent antibiotics that are less prone to resistance development in bacterial pathogens. To facilitate the search of such compounds, a transglycosylase (TGase) domain of the membrane integral multidomain Streptococcus pneumoniae PBP1b was cloned and expressed. This TGase do...

journal_title：Bioorganic & medicinal chemistry

authors： Liu H,Wong CH

更新日期：2006-11-01 00:00:00

abstract：:Nociceptin (NOC) and dynorphin A (DYN) analogues containing 2',6'-dimethylphenylalanine (Dmp) in place of Phe or Tyr in position 1 and/or 4 were synthesized and their metabolic stability and receptor-binding properties were investigated. [Dmp1]NOC(1-13)-NH2 (1) possessed high ORL1 receptor affinity comparable to that ...

journal_title：Bioorganic & medicinal chemistry

authors： Sasaki Y,Kawano S,Kohara H,Watanabe H,Ambo A

更新日期：2006-04-01 00:00:00