Thiopyrano[2,3-e]indol-2-ones: angelicin heteroanalogues with potent photoantiproliferative activity.


:A new class of compounds, the thiopyrano[2,3-e]indol-2-ones, bioisosters of the angular furocoumarin angelicin, was synthesized with the aim of obtaining new photochemotherapeutic agents. In particular 7,8-dimethyl-thiopyranoindolone 6c s showed a remarkable phototoxicity and a great dose UVA dependence reaching IC(50) values at submicromolar level. This latter photoinduced a massive apoptosis and a remarkable photodamage to lipids and proteins. Although it did not intercalate DNA, it was able to cause photooxidation of DNA bases.


Bioorg Med Chem


Barraja P,Diana P,Montalbano A,Carbone A,Cirrincione G,Viola G,Salvador A,Vedaldi D,Dall'acqua F




Has Abstract


2008-11-15 00:00:00














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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Nguyen JT,Velázquez CA,Knaus EE

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    pub_type: 杂志文章


    authors: Sampson D,Zhu XY,Eyunni SV,Etukala JR,Ofori E,Bricker B,Lamango NS,Setola V,Roth BL,Ablordeppey SY

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Wellington KW,Kolesnikova NI

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Salerno L,Pittalà V,Romeo G,Modica MN,Siracusa MA,Di Giacomo C,Acquaviva R,Barbagallo I,Tibullo D,Sorrenti V

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Li GL,Cai CY,He JY,Rao L,Ma L,Liu Y,Wang B

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    更新日期:2002-02-01 00:00:00

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Fatthalla MI,Elkholy YM,Abbas NS,Mandour AH,Jørgensen PT,Bomholt N,Pedersen EB

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Emirdağ-Öztürk S,Karayildirim T,Anil H

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Montero-Torres A,Vega MC,Marrero-Ponce Y,Rolón M,Gómez-Barrio A,Escario JA,Arán VJ,Martínez-Fernández AR,Meneses-Marcel A

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    journal_title:Bioorganic & medicinal chemistry

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Basu D,Richters A,Rauh D

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Alam MS,Huang J,Ozoe F,Matsumura F,Ozoe Y

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    更新日期:2000-06-01 00:00:00

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Kumar M,Singh K,Ngwane AH,Hamzabegovic F,Abate G,Baker B,Wiid I,Hoft DF,Ruminski P,Chibale K

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    更新日期:2020-08-28 00:00:00

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Wolin RL,Santillán A Jr,Tang L,Huang C,Jiang X,Lovenberg TW

    更新日期:2004-08-15 00:00:00

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    更新日期:2017-09-15 00:00:00

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Nim-Anussornkul D,Vilaivan T

    更新日期:2017-12-15 00:00:00

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Cavalier JF,Burton M,Dussart F,Marchand C,Rees JF,Marchand-Brynaert J

    更新日期:2001-04-01 00:00:00