Abstract:
:This work investigated the in vitro and in vivo anti-angiogenic activity of some pyrroloazaflavones, exactly 2-phenyl-1H-pyrrolo[2,3-h]quinolin-4(7H)ones, with vinblastine as reference compound. Growth inhibitory activity, migration, and capillary-like structures formation were determined in human umbilical vein endothelial cell cultures, and Matrigel plug assay was carried out to evaluate in vivo effects on angiogenesis. Collectively, our results indicate that some pyrroloazaflavone derivatives, at non-cytotoxic concentrations and like vinblastine are able: (i) to exert in vitro anti-angiogenic activity and (ii) to counteract in vitro and in vivo the pro-angiogenic effects of fibroblast growth factor-2 (FGF-2).
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Ferlin MG,Conconi MT,Urbani L,Oselladore B,Guidolin D,Di Liddo R,Parnigotto PPdoi
10.1016/j.bmc.2010.11.010subject
Has Abstractpub_date
2011-01-01 00:00:00pages
448-57issue
1eissn
0968-0896issn
1464-3391pii
S0968-0896(10)01023-0journal_volume
19pub_type
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