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Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines.

Abstract：

:Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

de Fatima A,Kohn LK,Antônio MA,de Carvalho JE,Pilli RA

doi

10.1016/j.bmc.2004.07.044

subject

Has Abstract

pub_date

2004-10-15 00:00:00

pages

5437-42

issue

20

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(04)00552-8

journal_volume

12

pub_type

杂志文章

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