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Facile preparation of deuterium-labeled N-acylhomoserine lactones as internal standards for isotope dilution mass spectrometry.

Abstract：

:N-Acylhomoserine lactones (AHLs) are widely conserved signal molecules that mediate quorum sensing in Gram-negative bacteria. In this study, deuterium-labeled AHLs were prepared for use as internal standards for isotope dilution mass spectrometry. Their utility in the sensitive and precise quantification of AHLs in culture supernatants of bacteria by GC/MS was demonstrated.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Kai K,Tani A,Hayashi H

doi

10.1016/j.bmc.2010.04.055

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

3776-82

issue

11

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00367-6

journal_volume

18

pub_type

杂志文章

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