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Synthesis and antimicrobial activity of dermaseptin S1 analogues.

Abstract：

:Dermaseptins are peptides found in the skin secretions of Phyllomedusinae frogs. These peptides exert lytic action on some microorganisms without substantial haemolysis. In an attempt to understand the antimicrobial activity of these peptides we designed several dermaseptin S1 (ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ) (DS1) analogues. All peptides were tested on the growth of prokaryotic (Gram-positive and Gram-negative bacteria) and eukaryotic (the yeast Candida albicans and the protozoon Leishmania major) organisms. Our data showed a dose-dependent killing effect by most DS1 derivatives. Maximal antibacterial activity was displayed by a 16-mer peptide that was more active than native DS1.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Savoia D,Guerrini R,Marzola E,Salvadori S

doi

10.1016/j.bmc.2008.07.032

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

8205-9

issue

17

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)00645-7

journal_volume

16

pub_type

杂志文章

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