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Synthesis of chondroitin sulfate CC and DD tetrasaccharides and interactions with 2H6 and LY111.

Abstract：

:We synthesized the biotinylated chondroitin sulfate tetrasaccharides CS-CC [-3)βGalNAc6S(1-4)βGlcA(1-]2 and CS-DD [-3)βGalNAc6S(1-4)βGlcA2S(1-]2 which possess sulfate groups at O-6 of GalNAc and an additional sulfate group at O-2 of GlcA, respectively. We also analyzed interactions among CS-CC and CS-DD and the antibodies 2H6 and LY111, both of which are known to bind with CS-A, while CS-DD was shown for the first time to bind with both antibodies.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Matsushita K,Nakata T,Takeda-Okuda N,Nadanaka S,Kitagawa H,Tamura JI

doi

10.1016/j.bmc.2018.01.011

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

1016-1025

issue

5

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(17)32396-9

journal_volume

26

pub_type

杂志文章

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