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Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3',5'-cyclic monophosphate derivatives.

Abstract：

:Synthetic derivatives of cyclic adenosine monophosphate, such as halogenated or other more hydrophobic analogs, are widely used compounds, to investigate diverse signal transduction pathways of eukaryotic cells. This inspired us to develop cyclic nucleotides, which exhibit chemical structures composed of brominated 7-deazaadenines and the phosphorylated ribosugar. The synthesized 8-bromo- and 7-bromo-7-deazaadenosine-3',5'-cyclic monophosphates rank among the most potent activators of cyclic nucleotide-regulated ion channels as well as cAMP-dependent protein kinase. Moreover, these substances bind tightly to exchange proteins directly activated by cAMP.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Lelle M,Otte M,Thon S,Bertinetti D,Herberg FW,Benndorf K

doi

10.1016/j.bmc.2019.03.024

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

1704-1713

issue

8

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(19)30217-2

journal_volume

27

pub_type

杂志文章

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