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Anti-inflammatory profile of some synthesized heterocyclic pyridone and pyridine derivatives fused with steroidal structure.

Abstract：

:We herein report the anti-inflammatory activity of some newly synthesized heterocyclic pyridone and pyridine derivatives fused with steroidal structure. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). All compounds, except 3b, 22, and 23, were interestingly less toxic than the reference drug (Prednisolone). Regarding the protection against Carrageenan-induced edema, eight compounds were found to be more potent than Prednisolone. On the other hand, in searching for COX-2 inhibitor, the inhibition of plasma PGE2 for the compounds was determined and four compounds were found to be more potent than the reference drug. The structure assignment of the new compounds was based on chemical and spectroscopic evidence.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Amr AG,Abdulla MM

doi

10.1016/j.bmc.2006.02.045

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

4341-52

issue

13

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)00196-9

journal_volume

14

pub_type

杂志文章

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