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Mechanism of the melanogenesis stimulation activity of (-)-cubebin in murine B16 melanoma cells.

Abstract：

:(-)-Cubebin showed a melanogenesis stimulation activity in a concentration-dependent manner in murine B16 melanoma cells without any significant effects on cell proliferation. Tyrosinase activity was increased at 24-72 h after addition of cubebin to B16 cells, and then intracellular melanin amount was increased at 48-96 h after the treatment. The expression levels of tyrosinase were time-dependently enhanced after the treatment with cubebin. At the same time, the expression levels of tyrosinase mRNA were also increased after addition of cubebin. Furthermore Western blot analysis revealed that cubebin elevated the level of phosphorylation of p38 mitogen-activated protein kinase (MAPK). SB203580, a selective inhibitor of p38 MAPK, completely blocked cubebin-induced expression of tyrosinase mRNA in B16 cells. These results suggested that cubebin increased melanogenesis in B16 cells through the enhancement of tyrosinase expression mediated by activation of p38 MAPK.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Hirata N,Naruto S,Ohguchi K,Akao Y,Nozawa Y,Iinuma M,Matsuda H

doi

10.1016/j.bmc.2007.04.046

subject

Has Abstract

pub_date

2007-07-15 00:00:00

pages

4897-902

issue

14

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00373-2

journal_volume

15

pub_type

杂志文章

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