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Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents.

Abstract：

:Novel pyrazolyl-2,4-thiazolidinediones were prepared via the reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinediones and substituted benzyl-2,4-thiazolidinediones. The resultant compounds were first evaluated for their anti-inflammatory and neuroprotective properties in vitro. The active compounds were further studied in vivo by using the formalin-induced paw edema and the turpentine oil-induced granuloma pouch bioassays. We identified four novel compounds that showed protective effects in vitro at non-toxic concentrations, and were also effective in the animal models of acute and sub-acute inflammation.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Youssef AM,White MS,Villanueva EB,El-Ashmawy IM,Klegeris A

doi

10.1016/j.bmc.2010.01.021

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

2019-28

issue

5

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00042-8

journal_volume

18

pub_type

杂志文章

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