New triterpenoid saponins with strong alpha-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana.

Abstract:

:Seven new triterpenoid saponins (1-7), have been isolated and elucidated from the roots of Gypsophila oldhamiana together with five known triterpenoid saponins (8-12). These saponins which could be classified into three series: 3-O-monoglucosides (1, 8, 9), 28-O-monoglucosides (2-4, 12) and 3, 28-O-bidesmosides (5-7, 10, 11), have been evaluated for their alpha-glucosidase inhibition activity. As a result, the preliminary structure-activity relationships were discussed based on the position of sugar linkage attached to the aglycone, and 28-O-monoglucosides 2-4 and 12 showed significant inhibitory activities on alpha-glucosidase.

journal_name

Bioorg Med Chem

authors

Luo JG,Ma L,Kong LY

doi

10.1016/j.bmc.2007.12.053

subject

Has Abstract

pub_date

2008-03-15 00:00:00

pages

2912-20

issue

6

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)01123-6

journal_volume

16

pub_type

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