Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides.

Abstract:

:A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, the new derivatives showed an improved cytotoxic activity over amonafide. DNA binding experiments supported that this class of compounds behaves as effective DNA-intercalating agents.

journal_name

Bioorg Med Chem

authors

Li F,Cui J,Guo L,Qian X,Ren W,Wang K,Liu F

doi

10.1016/j.bmc.2007.05.032

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

5114-21

issue

15

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00449-X

journal_volume

15

pub_type

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