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Design, synthesis, in vitro, and in silico studies of novel diarylimidazole-1,2,3-triazole hybrids as potent α-glucosidase inhibitors.

Abstract：

:In this work, new derivatives of diarylimidazole-1,2,3-triazole 7a-p were designed, synthesized, and evaluated for their in vitro α-glucosidase inhibitory activity. All compounds showed potent inhibitory activity in the range of IC50 = 90.4-246.7 µM comparing with acarbose as the standard drug (IC50 = 750.0 µM). Among the synthesized compounds, compounds 7b, 7c, and 7e were approximately 8 times more potent than acarbose. The kinetic study of those compounds indicated that they acted as the competitive inhibitors of α-glucosidase. Molecular docking studies were also carried out for compounds 7b, 7c, and 7e using modeled α-glucosidase to find the interaction modes responsible for the desired inhibitory activity.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Saeedi M,Mohammadi-Khanaposhtani M,Asgari MS,Eghbalnejad N,Imanparast S,Faramarzi MA,Larijani B,Mahdavi M,Akbarzadeh T

doi

10.1016/j.bmc.2019.115148

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

115148

issue

23

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(19)30848-X

journal_volume

27

pub_type

杂志文章

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