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A new and efficient synthesis of substituted 6-[(2'-dialkylamino)ethyl] pyrimidine and 4-N,N-dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-rubella activity.

Abstract：

:New 6-[(2'-dialkylamino)ethyl]-4(3H)-pyrimidinones were prepared by a multistep procedure starting from acetone dicarboxylic acid diethyl ester and urea derivatives. These compounds were used as starting materials to obtain 4-N,N-dialkyl-6-vinyl-pyrimidine derivatives by an unprecedented tandem C-6 side chain Hofmann-like elimination/C-4 pyrimidinone substitution. Among the new derivatives obtained, various compounds show anti-Rubella activity. The inhibition of HIV-1 Reverse Transcriptases (RT), from both wild type and modified viruses, is also reported.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Saladino R,Ciambecchini U,Maga G,Mastromarino P,Conti C,Botta M

doi

10.1016/s0968-0896(02)00077-9

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

2143-53

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968089602000779

journal_volume

10

pub_type

杂志文章

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