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Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups.

Abstract：

:One phenol-quaternary ammonium salt derivative with a flexible linker and three derivatives with a quinazoline moiety are present. Their binding affinities for DNA are discussed and it is clearly demonstrated that this class of phenol-quaternary ammonium salt derivatives could inhibit DNA transcription effectively.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Zhang L,Ren L,Bai M,Weng L,Huang J,Wu L,Deng M,Zhou X

doi

10.1016/j.bmc.2007.07.053

subject

Has Abstract

pub_date

2007-11-15 00:00:00

pages

6920-6

issue

22

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00686-4

journal_volume

15

pub_type

杂志文章

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