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Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro.

Abstract：

:The hepatitis C virus (HCV) NS3/4A protease that plays an important role in the viral life cycle has been proven to be an excellent target for the discovery of anti-HCV drugs. Enlightened by some P2-triazole and amide compounds, which had been found as HCV NS3 protease inhibitors, we designed and synthesized a series of novel compounds by incorporating different amino acid residues in P1/P1' and P3/P3' position to develop novel antiviral agents. The result of enzyme inhibition assay indicated that all the designed compounds showed moderate anti-HCV NS3 protease activity. On the basis of the biological result, a detailed structure-activity relationship (SAR) was derived and discussed.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Shi F,Zhang Y,Xu W

doi

10.1016/j.bmc.2015.07.032

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

5539-45

issue

17

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(15)00616-1

journal_volume

23

pub_type

杂志文章

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