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Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2.

Abstract：

:Because the activation of matrix metalloproteinases (MMP) is a key factor in the metastatic process, compounds with the ability to inhibit MMP activity have a potential in the treatment of tumor. From the examination of 2000 plant extracts, obovatal isolated from the extract of the leaves of Magnolia obovata THUNB was a potent inhibitor of MMP-2 enzyme in vitro. In human fibrosarcoma cells (HT1080) activated with MMP-2, obovatal inhibited MMP-2 enzyme activity and expression. In addition, the compound blocked migration and invasion of the cells. This study demonstrates that obovatal exerts its anticancer effects through blocking migration and invasion by inhibition of MMP-2 expression and activity, and also will be a good lead molecule for the development of anti-tumor drug.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Lee SK,Chun HK,Yang JY,Han DC,Son KH,Kwon BM

doi

10.1016/j.bmc.2007.03.081

subject

Has Abstract

pub_date

2007-06-15 00:00:00

pages

4085-90

issue

12

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00293-3

journal_volume

15

pub_type

杂志文章

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