Abstract:
:Six new polyketides aplojaveediins A-F (1-6) were isolated from the endophytic fungus Aplosporella javeedii associated with the host plant Orychophragmus violaceus (Brassicaceae). The structures of the new metabolites were elucidated by analysis of their NMR and MS data. Compound 1 exhibited antifungal activity against the hyphae form of Candida albicans strain ATCC 24433 in the agar plate diffusion assay and the microbroth dilution assay. The kinetic of killing of C. albicans cells for compound 1 was considerably faster than that of the positive control hygromycin B. Compounds 1 and 6 also exhibited moderate antibacterial activities against sensitive (ATCC 29213) and drug-resistant (ATCC 700699) strains of Staphylococcus aureus.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Gao Y,Wang L,Kalscheuer R,Liu Z,Proksch Pdoi
10.1016/j.bmc.2020.115456subject
Has Abstractpub_date
2020-05-15 00:00:00pages
115456issue
10eissn
0968-0896issn
1464-3391pii
S0968-0896(20)30270-4journal_volume
28pub_type
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