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Antifungal polyketide derivatives from the endophytic fungus Aplosporella javeedii.

Abstract：

:Six new polyketides aplojaveediins A-F (1-6) were isolated from the endophytic fungus Aplosporella javeedii associated with the host plant Orychophragmus violaceus (Brassicaceae). The structures of the new metabolites were elucidated by analysis of their NMR and MS data. Compound 1 exhibited antifungal activity against the hyphae form of Candida albicans strain ATCC 24433 in the agar plate diffusion assay and the microbroth dilution assay. The kinetic of killing of C. albicans cells for compound 1 was considerably faster than that of the positive control hygromycin B. Compounds 1 and 6 also exhibited moderate antibacterial activities against sensitive (ATCC 29213) and drug-resistant (ATCC 700699) strains of Staphylococcus aureus.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Gao Y,Wang L,Kalscheuer R,Liu Z,Proksch P

doi

10.1016/j.bmc.2020.115456

subject

Has Abstract

pub_date

2020-05-15 00:00:00

pages

115456

issue

10

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(20)30270-4

journal_volume

28

pub_type

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