Abstract:
:The relationships between inflammation in organs with Toxocara canis larval migration and matrix metalloproteinase-9 (MMP-9) were investigated following the infection of mice with 1,000 infective eggs. Gelatinase activity was defined by gelatin zymography, optimum pH, inhibitor specificity and Western blot analysis. MMP-9 activity was present in the lungs, liver, muscles, and brain during T. canis larval migration. This enzyme had a molecular weight of about 94 kDa and showed maximum activity in the pH range of 6-8. The increased MMP-9 proteinases coincided with larval recovery and the degree of inflammation among the four organs. These results suggest that MMP-9 may be associated with the inflammatory reaction to larval toxocariasis during early migration, and may therefore be a useful marker during T. canis larvae migration.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Lai SC,Chen KM,Chen HC,Lee HHdoi
10.1007/s00436-004-1271-9subject
Has Abstractpub_date
2005-02-01 00:00:00pages
193-200issue
3eissn
0932-0113issn
1432-1955journal_volume
95pub_type
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