Abstract：
:Whole sequencing of protozoan trypanosomatid genomes revealed the presence of several predicted unknown genes coding for hypothetical proteins. Pairwise, alignment-based, computational methods available online are unable to identify the function of these sequences. To detect clues to identify the function of hypothetical proteins, a user-friendly, bioinformatic tool named PROTOzoan Gene Identification Motifs (PROTOGIM, available on http://www.biowebdb.org/protogim ) was developed, which allows the user to search functional patterns of hypothetical proteins through the screening of regular expression in the sequences. The analysis of 1,194 trypanosomatid hypothetical proteins through PROTOGIM resulted in an identification of motifs and domains in 98% of the cases, demonstrating the reliability and accuracy of the employed method. The added value of this tool is the possibility to modify or insert new regular expressions to perform an analysis against either one or several sequences at the same time. An in silico strategy along with biochemical and molecular characterizations creates new possibilities to find the functions of hypothetical proteins at the postgenome era.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Cestari IS,Haver NJ,Barbosa-Silva A,Ramirez MIdoi
10.1007/s00436-005-0064-0subject
Has Abstractpub_date
2006-03-01 00:00:00pages
375-7issue
4eissn
0932-0113issn
1432-1955journal_volume
98pub_type
杂志文章abstract：:Bats from the families Rhinolophidae (n = 90) and Vespertilionidae (n = 191) in the USA and Czech Republic were screened for the presence of Cryptosporidium by microscopic and molecular analysis of faecal samples collected from rectum of dissected animals and from the ground beneath roosting sites. Cryptosporidium ooc...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4654-1
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abstract：:Equine ocular setariasis arising mainly from ectopic infestation of Setaria digitata is a common vision impairing ophthalmic disease in India, and the identification of this filarial nematode is based solely on morphology. However, morphological characters alone are inadequate to detect and differentiate S. digitata f...
journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
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更新日期：2020-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-2968-9
更新日期：2012-09-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050681
更新日期：2000-05-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050693
更新日期：2000-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0781-7
更新日期：2008-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1835-9
更新日期：2010-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1024-2
更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00436-018-6052-y
更新日期：2018-11-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-0948-x
更新日期：2008-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931834
更新日期：1993-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050590
更新日期：1999-07-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0743-0
更新日期：2008-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0382-x
更新日期：2007-04-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2015-11-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050703
更新日期：2000-06-01 00:00:00
abstract：:Reports of an unusual intraerythrocytic pathogen in amphibian blood have been made for decades; these pathogens appear as membrane-bound vacuoles within erythrocytes. It is now understood that the pathogen is a Rickettsia bacteria, which are obligate intracellular parasites, and most are transmitted by arthropod vecto...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1869-z
更新日期：2010-07-01 00:00:00
abstract：:There appear to be few reports in the literature regarding the host-poultry red mite (Dermanyssus gallinae) immunological relationship, despite the negative impact D. gallinae can have on both bird welfare and egg production, as well as its potential to act as a reservoir of zoonotic infections. The current study inve...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1821-2
更新日期：2010-05-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931649
更新日期：1992-01-01 00:00:00
abstract：:The oncomiracidium (larva) of the entobdelline Neoentobdella parvitesticulata (Monogenea: Capsalidae), adults of which parasitise the skin of the stingray Himantura fai (Dasyatidae) at Heron Island, Great Barrier Reef, Queensland, Australia, is described. The larva undergoes precocious development (progenesis) in the ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-005-1399-2
更新日期：2005-07-01 00:00:00
abstract：:Spawning individuals of allis shad, Alosa alosa (Linnaeus, 1758), and twaite shad, Alosa fallax (Lacépède, 1803), were sampled from three rivers on the Atlantic coast of the Iberian Peninsula (Ulla, Minho, Mondego) during 2008 to 2013 to assess the presence of the zoonotic marine parasite Anisakis spp. larvae. The res...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4403-5
更新日期：2015-06-01 00:00:00
abstract：:The efficacy of emodepside plus toltrazuril (Procox® oral suspension for dogs) against different species of gastrointestinal nematodes (Toxocara canis, Ancylostoma caninum, Uncinaria stenocephala) was evaluated in nine randomised,blinded and placebo-controlled laboratory studies in naturally or experimentally infected...
journal_title：Parasitology research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00436-011-2397-1
更新日期：2011-08-01 00:00:00
