Ultrastructural alterations induced by nifurtimox and another nitro derivative on epimastigotes of Trypanosoma cruzi.

Abstract:

:We report the ultrastructural alterations induced on epimastigotes by nifurtimox and 5-nitro-2-thienyl-malononitrile (5NO2TM), a novel compound with anti-Trypanosoma cruzi activity. Parasites treated with concentrations of nifurtimox lower than usually employed for this kind of study showed vacuolisation, alterations of the mitochondria, the nucleus and the ribosomes. 5NO2TM caused the same kind of damage, but to a greater degree. This result correlates with the fact that cultures treated with this compound experienced a greater loss of viability.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Muelas-Serrano S,Pérez-Serrano J,Gómez-Barrio A,Arán VJ,Rodríguez-Caabeiro F

doi

10.1007/s004360100497

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

97-101

issue

2

eissn

0932-0113

issn

1432-1955

journal_volume

88

pub_type

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