Abstract:
:We report the ultrastructural alterations induced on epimastigotes by nifurtimox and 5-nitro-2-thienyl-malononitrile (5NO2TM), a novel compound with anti-Trypanosoma cruzi activity. Parasites treated with concentrations of nifurtimox lower than usually employed for this kind of study showed vacuolisation, alterations of the mitochondria, the nucleus and the ribosomes. 5NO2TM caused the same kind of damage, but to a greater degree. This result correlates with the fact that cultures treated with this compound experienced a greater loss of viability.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Muelas-Serrano S,Pérez-Serrano J,Gómez-Barrio A,Arán VJ,Rodríguez-Caabeiro Fdoi
10.1007/s004360100497subject
Has Abstractpub_date
2002-02-01 00:00:00pages
97-101issue
2eissn
0932-0113issn
1432-1955journal_volume
88pub_type
杂志文章abstract::Efforts to derive a physical map of the genome of Eimeria tenella are being made to complement genetic mapping and to assist in the production of an integrated map. A large insert library of DNA from the Houghton (H) reference strain of E. tenella has been constructed in yeast artificial chromosomes (YACs). The librar...
journal_title:Parasitology research
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