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An immunocytochemical method for marking microelectrode tracks following single-unit recordings in long surviving, awake monkeys.

Abstract：

:We describe an immunocytochemical method for marking microelectrode tracks made during single-unit recordings in long surviving, awake monkeys. This procedure detects the increase in glial fibrillary acidic protein in the glial cells along a microelectrode track using commercially available antibodies. We have successfully marked electrode tracks in tissue from preparations having postrecording survival times ranging into months even though the gliosis can no longer be detected with conventional stains for cell bodies. When this method is combined with data from electrophysiological recordings in chronic preparations it will be possible to reconstruct functional architecture using chronic preparations, as has been done previously with acute preparations.

journal_name

J Neurosci Methods

journal_title

Journal of neuroscience methods

authors

Benevento LA,McCleary LB

doi

10.1016/0165-0270(92)90085-r

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

199-204

issue

3

eissn

0165-0270

issn

1872-678X

pii

0165-0270(92)90085-R

journal_volume

41

pub_type

杂志文章

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