Physiological monitoring of small animals during magnetic resonance imaging.

Abstract:

:Maintaining a stable physiologic state is essential when studying animal models of epilepsy with simultaneous electroencephalograph (EEG) and functional magnetic resonance imaging (fMRI) or EEG and magnetic resonance spectroscopy (MRS). To achieve and maintain such stability in rats in the MRI environment, a minimally invasive but comprehensive system was developed to monitor body temperature, heart rate, blood pressure, blood oxygen saturation and end-tidal CO2 (ETCO2) of expired gas. All physiologic parameters were successfully monitored in Sprague-Dawley rats without interfering with EEG recordings during simultaneous fMRI and MRS studies. Body temperature, heart rate, blood pressure, blood oxygen saturation, and ETCO2, were maintained between 36.5 and 37.5 degrees C, 250-450 beats/min, 136+/-17 mmHg, >90%, and 20-35 mmHg, respectively for 6-8 h under inhalational anesthesia. This set-up could be extended to study in vivo applications in other laboratory animals with only minor modifications.

journal_name

J Neurosci Methods

authors

Mirsattari SM,Bihari F,Leung LS,Menon RS,Wang Z,Ives JR,Bartha R

doi

10.1016/j.jneumeth.2004.11.019

subject

Has Abstract

pub_date

2005-06-15 00:00:00

pages

207-13

issue

2

eissn

0165-0270

issn

1872-678X

pii

S0165-0270(04)00411-X

journal_volume

144

pub_type

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